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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: VCP All Species: 54.55
Human Site: T249 Identified Species: 100
UniProt: P55072 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P55072 NP_009057.1 806 89322 T249 L L Y G P P G T G K T L I A R
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_852626 806 89284 T249 L L Y G P P G T G K T L I A R
Cat Felis silvestris
Mouse Mus musculus Q3UMC0 893 97237 T398 L L Y G P P G T G K T M I A R
Rat Rattus norvegicus P46462 806 89330 T249 L L Y G P P G T G K T L I A R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001520419 805 89553 T248 L L Y G P P G T G K T L I A R
Chicken Gallus gallus NP_001038129 806 89306 T249 L L Y G P P G T G K T L I A R
Frog Xenopus laevis P23787 805 89193 T249 L L Y G P P G T G K T L I A R
Zebra Danio Brachydanio rerio Q7ZU99 806 89405 T249 L L Y G P P G T G K T L I A R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q7KN62 801 88841 T246 L M Y G P P G T G K T L I A R
Honey Bee Apis mellifera XP_392892 800 88877 T246 L L Y G P P G T G K T L I A R
Nematode Worm Caenorhab. elegans P54812 810 89622 T254 L L F G P P G T G K T L I A R
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LZF6 810 89940 S252 L L Y G P P G S G K T L I A R
Baker's Yeast Sacchar. cerevisiae P25694 835 91977 T259 L M Y G P P G T G K T L M A R
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. N.A. 99.8 N.A. 38.5 99.8 N.A. 97.8 99 96.6 96.7 N.A. 83.1 83.6 78.7 N.A.
Protein Similarity: 100 N.A. N.A. 99.8 N.A. 57.1 100 N.A. 98.3 99.7 98.8 98.7 N.A. 92 93 89.2 N.A.
P-Site Identity: 100 N.A. N.A. 100 N.A. 93.3 100 N.A. 100 100 100 100 N.A. 93.3 100 93.3 N.A.
P-Site Similarity: 100 N.A. N.A. 100 N.A. 100 100 N.A. 100 100 100 100 N.A. 100 100 100 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 77.1 67.5 N.A.
Protein Similarity: N.A. N.A. N.A. 87.6 83.2 N.A.
P-Site Identity: N.A. N.A. N.A. 93.3 86.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 100 100 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 100 0 0 100 0 100 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 93 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 % K
% Leu: 100 85 0 0 0 0 0 0 0 0 0 93 0 0 0 % L
% Met: 0 16 0 0 0 0 0 0 0 0 0 8 8 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 100 100 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 % R
% Ser: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 93 0 0 100 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 93 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _